Molecular Docking Senyawa pada Buah Mengkudu (Morinda Citrifolia L.) terhadap Reseptor PDGFR-a sebagai Kandidat Antikanker Paru-Paru
DOI:
https://doi.org/10.33482/jmedfarm.v3i1.62Kata Kunci:
Molecular docking, Mengkudu, PDGFR-αAbstrak
Pendahuluan: Reseptor PDGFR-α termasuk salah satu reseptor protein dalam perkembangan kanker paru-paru dengan mengatur proliferasi, angiogenesis, dan migrasi sel kanker. Penggunaan obat sintetik terhadap sel kanker sering kali menargetkan sel normal sehingga timbul efek samping pada penderita. Karena hal ini perlu dikembangkan senyawa antikanker yang berasal dari bahan alam yang minim efek samping dari pada obat sintetik. Pada penelitian ini digunakan senyawa yang terkandung pada buah mengkudu. Metode: Penelitian ini menggunakan metode molecular docking dengan melihat skor docking terendah antara empat senyawa yang paling banyak terkandung dalam buah mengkudu dan Gemcitabin sebagai kontrol positif terhadap reseptor PDGFR-α. Hasil: Setelah dilakukan molecular docking, senyawa dengan interaksi paling baik diantara yang lain adalah Nordamnacanthal dengan skor docking -6,49, diikuti dengan Morindone, α-Pinene, Gemcitabine, dan L-Scopoletin dengan skor docking secara berurutan yaitu -5,01; -4,83; -4,77; dan -4,66. Kesimpulan. Senyawa Nordamnacanthal memiliki skor docking lebih rendah dari pada Gemcitabin yang merupakan obat sintetik yang telah ada untuk mengobati kanker paru-paru, sehingga Nordamnacanthal bisa menjadi kandidat obat anti kanker paru-paru yag berasal dari senyawa bahan alam.
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