Artikel Review: Tanaman yang Memiliki Potensi sebagai Antikanker Payudara
DOI:
https://doi.org/10.33482/jmedfarm.v3i1.58Kata Kunci:
Senyawa alami, anti-kanker payudara, in silico , in vitro, in vivoAbstrak
Pendahuluan: Penelitian ini mengkaji peran farmakoterapi dalam penyakit sistem imun dan kanker, dengan menyoroti potensi senyawa alami sebagai agen antikanker. Studi ini me-review berbagai penelitian yang menggunakan pendekatan in silico, in vitro, dan in vivo untuk mengevaluasi aktivitas antikanker dari berbagai ekstrak tumbuhan dan senyawa bioaktif. Metode: Review artikel ini menggunakan referensi yang diperoleh dari penelusuran database dengan instrumen pencarian online yang diterbitkan secara nasional dan internasional. Hasil: Hasil analisis menunjukkan bahwa senyawa alami berkontribusi dalam penghambatan pertumbuhan sel kanker melalui mekanisme apoptosis, aktivitas antioksidan, dan pengurangan inflamasi. Berbagai jalur molekuler seperti HER2, survivin, EGFR, Nrf2-Keap1, dan PI3K/AKT/mTOR menjadi target utama dalam pengembangan terapi berbasis senyawa alami. Bukti yang dikumpulkan mengindikasikan bahwa senyawa alami memiliki potensi besar sebagai terapi kanker inovatif yang lebih aman dan efektif. Kesimpulan: Didapatkan data 13 tanaman yang memiliki potensi sebagai agen antikanker dalam terapi kanker payudara, dengan mekanisme kerja meliputi induksi apoptosis, penghambatan proliferasi sel kanker, modulasi sistem imun, serta regulasi jalur pensinyalan molekuler.
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